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KMID : 0377619750290050449
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Korean Jungang Medical Journal
1975 Volume.29 No. 5 p.449 ~ p.455
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Studies on the Changes in Serum Calcium, Phosphorus and Alkaline Phophatase in Fracture Healing
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Abstract
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It is now generally recognized that the determination of serum calcium, inorganic phosphorus, and phosphatase activity, in conjunction with clinical and roentgenologic studies, may provide evidence of value in the differential diagnosis of certain diseases of bone.
Prior studies of fracture repair have been limited to histological description of the process, and only limited biochemical information correlating the metabolic characteristics of various tissue types constituting fracture callus with successful bone union have been reported.
Many investigators reported that there was close correlation between the amount of calcification and the phosphatase activity during the process of fracture healing.
girls nowadays there is strong evidence that the rapidity of healing of a fracture is dependent on the amount of phosphatase produced locally but there are varying ideas concerning the changes in the serum levels of calcium and alkaline phosphatase.
order is get useful ideas for clinical application in the treatment of fractures, the levels of serum calcium, phosphorus and alkaline phosphatase were checked periodically in an experimental group of 93 fracture patients.
The results obtained are summarized as follows:
l) Serum alkaline phosphatase level was significantly higher in the fracture healing
processes of growing children than in the same age range of the control group. 2) Alkaline phosphatase takes part in the formation of the preosseous matrix,
since serum alkaline phosphatase activity reached a peak 3 weeks following the
fracture.
3) Alkaline phosphatase activity was higher in males between 16 and 25 years of age, than in females, since growth maturation was not completed in this age group of males.
4) Serum calcium level reached a maximum after 6 weeks following fracture in
analysis of the experimental group, however it was not significant compared with the control group.
5) There was no change in serum phosphorus level.
6) There was no difference in serum calcium- and phosphorus levels between the sexes.
7) There was no difference in the alkaline phosphatase level between the multiple and single fracture groups.
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